All eyes will be on Old Trafford this weekend for the first heavyweight clash of the 2009/10 campaign.
Arsenal fans will discover if their team can truly put up a realistic title challenge when they visit Old Trafford to take on champions Manchester United on Saturday.
The Gunners were thought by many to be the team most susceptible to succumb to the challenge of mega rich Manchester City, with their top four place supposedly in jeopardy this season.
Such a prediction now seems well wide of the mark with Arsene Wenger's men winning all four of their opening games this term, scoring 15 goals in the process.
But Arsenal know the real work begins this weekend when two of the 'big four' meet for the first time this season.
The Red Devils have history for bringing their London rivals back down to earth. Goals from Ruud van Nistelrooy and Wayne Rooney put an end to Arsenal's 49-game unbeaten run in 2004 while United's thumping 4-1 semi-final aggregate win over the Gunners last season ended any hopes Wenger had of lifting the UEFA Champions League.
However the Frenchman will take comfort from the fact that the sting that accompanied many of the two sides' previous encounters down the years has disappeared.
Easy on the eye
Gone are the ferocious personalities such as Roy Keane and Patrick Vieira, instead replaced by the composed and easy on the eye talents of Dimitar Berbatov, Michael Carrick, Cesc Fabregas and Andrey Arshavin.
However the Gunners' influential skipper has been ruled out due to the hamstring injury he picked up in the 4-1 win over Portsmouth last weekend.
Tomas Rosicky has now fully recovered from his long-term hamstring injury but he is expected to miss out at the Theatre of Dreams.
Aaron Ramsey, who could be an option to replace Fabregas, has had a scan on his knee after suffering in the Celtic clash in midweek. Although initial signs are positive the Welshman could still be ruled out.
Theo Walcott will also be assessed ahead of the clash following the back injury that has kept him out of the side so far this season.
Wenger will definitely be without the injured Samir Nasri (broken leg), Johan Djourou (knee) and Lukasz Fabianski (knee).
Meanwhile United will still be without the services of Rio Ferdinand (thigh), Edwin Van der Sar (finger) and Rafael (shoulder).
It should mean that Jonny Evans will continue to partner fit again Nemanja Vidic in defence after the Serbia international came through his first appearance of the season against Wigan unscathed.
Firepower
Van der Sar's injury means that Ben Foster should keep his place given he kept his second clean sheet of the season in a 5-0 win at the DW Stadium last weekend.
The debate rages on whether manager Sir Alex Ferguson has enough firepower at his disposal to cope with the loss of Cristiano Ronaldo and Carlos Tevez but Berbatov, Wayne Rooney and Michael Owen were all on target against the Latics.
United have already used the most players this season, 18, and Ferguson is likely to rotate his squad again on Saturday, in particular his midfield.
Paul Scholes and Darren Fletcher both started at Wigan but Ryan Giggs and Carrick, who missed out completely against Roberto Martinez's men, will be vying for a start as will Anderson, who will be looking to put his reported spat with Ferguson firmly behind him.
Possible starting XIs:
Man Utd: Foster, O'Shea, Evans, Vidic, Evra, Nani, Fletcher, Carrick, Valencia, Berbatov, Rooney.
Arsenal: Almunia, Sagna, Vermaelen, Gallas, Clichy, Song, Diaby, Denilson, Arshavin, Van Persie, Eduardo.